Tead4 is required for specification of trophectoderm in pre-implantation mouse embryos
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چکیده
منابع مشابه
Tead4 is required for specification of trophectoderm in pre-implantation mouse embryos
During pre-implantation mouse development, embryos form blastocysts with establishment of the first two cell lineages: the trophectoderm (TE) which gives rise to the placenta, and the inner cell mass (ICM) which will form the embryo proper. Differentiation of TE is regulated by the transcription factor Caudal-related homeobox 2 (Cdx2), but the mechanisms which act upstream of Cdx2 expression re...
متن کاملCdx2 gene expression and trophectoderm lineage specification in mouse embryos.
Controversy exists as to whether individual blastomeres from two-cell-stage mouse embryos have identical developmental properties and fate. We show that the transcription factor Cdx2 is expressed in the nuclei of cells derived from the late-dividing but not the first-dividing blastomere of two-cell embryos and, by lineage tracing and RNA interference knock-down experiments, that this lagging ce...
متن کاملMelatonin upregulates ErbB1 and ErbB4, two primary implantation receptors, in pre-implantation mouse embryos
Objective(s): To evaluated the effects of melatonin on early embryo competence and the expression rate of the primary implantation receptors (ErbB1 and ErbB4). Materials and Methods: Two-cell mouse embryos were cultured in 3 groups: simple media, melatonin-treated (10-9 M melatonin) and Luzindole-treated (10-9 M luzindole). Then, the rate of ErbB1 and ErbB4 gene and protein expression, the leve...
متن کاملCdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst.
Blastocyst formation marks the segregation of the first two cell lineages in the mammalian preimplantation embryo: the inner cell mass (ICM) that will form the embryo proper and the trophectoderm (TE) that gives rise to the trophoblast lineage. Commitment to ICM lineage is attributed to the function of the two transcription factors, Oct4 (encoded by Pou5f1) and Nanog. However, a positive regula...
متن کاملInitiation of trophectoderm lineage specification in mouse embryos is independent of Cdx2.
The separation of the first two lineages - trophectoderm (TE) and inner cell mass (ICM) - is a crucial event in the development of the early embryo. The ICM, which constitutes the pluripotent founder cell population, develops into the embryo proper, whereas the TE, which comprises the surrounding outer layer, supports the development of the ICM before and after implantation. Cdx2, the first tra...
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ژورنال
عنوان ژورنال: Mechanisms of Development
سال: 2008
ISSN: 0925-4773
DOI: 10.1016/j.mod.2007.11.002